Cell-cycle regulation of cohesin stability along fission yeast chromosomes

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Cell-cycle regulation of cohesin stability along fission yeast chromosomes.

Sister chromatid cohesion is mediated by cohesin, but the process of cohesion establishment during S-phase is still enigmatic. In mammalian cells, cohesin binding to chromatin is dynamic in G1, but becomes stabilized during S-phase. Whether the regulation of cohesin stability is integral to the process of cohesion establishment is unknown. Here, we provide evidence that fission yeast cohesin al...

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ژورنال

عنوان ژورنال: The EMBO Journal

سال: 2007

ISSN: 0261-4189,1460-2075

DOI: 10.1038/sj.emboj.7601955